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SENESCO CHOOSES VGXI TO PRODUCE FACTOR 5A PLASMID.

Senesco Technologies, Inc., (AMEX:SNT), Brunswwick, N.J., has contracted with VGXI, Inc. (The Woodlands, TX) ("VGXI") to supply the plasmid portion of the company's combination therapy consisting of the Factor 5A gene and siRNA against Factor 5A.

Senesco has previously reported positive

preclinical in vivo results using its combination siRNA and plasmid against subcutaneous multiple myeloma tumors in immunodeficient mice. The Factor 5A plasmid being produced by VGXI, as Senesco's preclinical data has shown, should cause cancer cells to enter apoptosis, or programmed cell death.

"VGXI's manufacturing and technical expertise in producing plasmids for Senesco's planned toxicology study and ultimately our clinical trial led us to choose them. We are pleased to be working with a company that has such an outstanding reputation in the field," commented Bruce Galton, Senesco's president and CEO.

Henry Hebel, vice president of Operations for VGXI said, "We believe that our ability to quickly supply the preclinical and clinical needs of our clients will allow Senesco to rapidly advance their programs. We are continuing to expand our collaborative development services to meet the growing needs for a wide variety of plasmid based products."

About VGXI Inc.

VGXI Inc. is a leading manufacturer of DNA plasmids, and its cGMP and non-cGMP products have passed rigorous reviews by several international regulatory agencies. VGXI offers a wide variety of contract manufacturing services to outside client organizations. The company's cGMP manufacturing facility in The Woodlands, Texas is a flexible, purpose-built facility used for research, development, and clinical supply. The site includes 500-liter and 100-liter fermentors and incorporates a cost-effective process. VGX International also has initiated a project to build and operate a 3000-liter scale cGMP, DNA plasmid manufacturing facility in Asia.

About Senesco Technologies, Inc.

Senesco Technologies, Inc. is a U.S. biotechnology company, headquartered in New Brunswick, NJ. Senesco has initiated preclinical research to trigger or delay cell death in mammals (apoptosis) to determine if the technology is applicable in human medicine. Accelerating apoptosis may have applications to development of cancer treatments. Delaying apoptosis may have applications to certain inflammatory and ischemic diseases. Senesco takes its name from the scientific term for the aging of plant cells: senescence. Delaying cell breakdown in plants extends freshness after harvesting, while increasing crop yields, plant size and resistance to environmental stress. The company believes that its technology can be used to develop superior strains of crops without any modification other than delaying natural plant senescence. Senesco has partnered with leading-edge companies engaged in agricultural biotechnology and earns research and development fees for applying its gene-regulating platform technology to enhance its partners' products.

For more information, vist http://www.senesco.com or call 281/296-7300.

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