Safety labeling changes approved by CDER--May 2007.
Desoxyn (methamphetamine hydrochloride tablets, USP) BOXED WARNING ... Misuse of methamphetamine may cause sudden death and serious cardiovascular adverse events. WARNINGS The following five subsections have been added: Serious Cardiovascular Events Sudden Death and Pre-existing Structural Cardiac Abnormalities or other Serious Heart Problems...

Pelvic-floor muscle function in women with pelvic organ prolapse.
Pelvic organ prolapse is the descent of the apex of the vagina or cervix (or vaginal vault after hysterectomy), anterior vaginal wall (previously referred to as "cystocele"), or posterior vaginal wall (previously called "rectocele"). (1) As prolapse progresses, organs can protrude outside the vaginal canal. This condition is common,...

Topical estrogen best treatment for advanced urogenital atrophy.
FORT LAUDERDALE, FLA. -- Topical estrogen is important to the success of treatment for urogenital atrophy and also has therapeutic value for the management of urinary urgency, frequency, and, most importantly, nocturia, Dr. G. Willy Davila said at a symposium on pelvic floor disorders sponsored by the Cleveland Clinic...

Evaluation of female pelvic-floor muscle function and strength.
Key Words: Evaluation, Function, Measurement, Pelvic-floor muscles, Reliability, Strength, Validity. Urinary incontinence is defined by the International Continence Society (ICS) as the complaint of any involuntary leakage of urine. (1) Urinary incontinence is more common in women than in men and affects women of all ages. Prevalence...

Cimicifuga racemosa extract BNO 1055 inhibits proliferation of the human prostate cancer cell line LNCaP.
Abstract Extracts from black cohosh (Cimicifuga racemosa, CR) exert an anti-proliferative action in human breast cancer cell cultures, which has been attributed to an anti-estrogenic effect. However, CR constituents do not bind to either of the known estrogen receptors. Thus, the anti-tumor effect of CR me be...

Effect of pelvic-floor muscle exercise position on continence and quality-of-life outcomes in women with stress urinary incontinence.
Stress urinary incontinence (SUI) is the involuntary loss of urine that occurs with physical exertion and a rise in abdominal pressure. (1) Coughing, sneezing, straining, jumping, and running are events commonly associated with SUI. Mechanisms underlying the development of SUI include pudendal nerve injury during vaginal delivery, (2) incomplete...

End-stage renal disease in people with type 2 diabetes: systemic manifestations and exercise implications.
[Evans N, Forsyth E. End-stage renal disease in people with type 2 diabetes: systemic manifestations and exercise implications.] Key Words: Diabetes, Exercise, Nephropathy, Systemic. Epidemiology In 1994, an estimated 12 million Americans had diabetes, and that number increased to 16 million in 1999....

Interstitial cystitis: understanding the syndrome.
Abstract Interstitial cystitis (IC) is a chronic pain syndrome that affects close to a million people in the United States. The syndrome presents differently in many individuals, with the unifying factor being chronic pelvic pain and disruption of daily life activities. Many etiologies have been proposed as...

Pharmacotherapy in the Treatment of Male Sexual Dysfunction.
The past ten years have witnessed significant advances in the treatment of men's sexual dysfunctions, many of which can be attributed to the introduction of effective pharmacologically-based therapies. Pharmacotherapy offers a range of proven options that can be used to treat sexual problems of varied and even unidentified causes....

The study of ejaculatory response in men in the psychophysiological laboratory.
Sexual psychophysiological researchers have had limited success in studying ejaculatory response in the laboratory in men and, more specifically, in identifying factors that differentiate the sexual response of men with premature ejaculation (PE) from controls. A number of methodological limitations may have contributed to the lack of effects in these...