Challenges in identifying genetic risk factors for common multifactorial disorders.
Advances in recombinant DNA technology have opened up many new diagnostic tools for monogenic disorders. DNA based techniques are also being used in the diagnosis of infectious diseases, and diagnosis and prognostication of cancers. Research in molecular pathogenesis of these disorders is likely to bring up new therapeutic strategies....

Molecular mechanisms for altered glucose homeostasis in HIV infection.
Abstract: A complete understanding of the molecular mechanisms leading to HIV-associated insulin resistance remains elusive. Complex interrelationships between genetic predisposition, disease-related body changes and multidrug therapy all contribute to alterations in glucose homeostasis. These abnormalities can be differentiated between acute and reversible changes directly induced by HAART medications and...

Genetics, family systems, and multicultural influences.
With groundbreaking advances in genomic research, the diagnosis, treatment, and prevention of most health and mental health disorders will increasingly be understood as having a genetic component. This article provides an overview of the family systems genetic illness (FSGI) model to address the psychosocial challenges of genomic conditions for...

Plan Akraman on diabetes.
India accounts for one-fourth of the global diabetic population, but this malady is still neglected. Being a juvenile diabetic means a very difficult life, but it was a prick of insulin everyday that kept speedster Wasim Akram going and making himself an icon in cricket. But not...

Study shows ten new genetic variants linked to type 2 diabetes.
IN THE MOST comprehensive look at genetic factors for type 2 diabetes, a US Finnish team who are working in collaboration with two other groups have identified at least four new genetic variants associated with increased risk of diabetes. Also confirmed is the existence of a possibility of another...

Dr. Rudolph Tanzi Makes Presentation at ICAD.
HEALTH AND BEAUTY CLOSE-UP-30 July 2008-Dr. Rudolph Tanzi Makes Presentation at ICAD(C)2008 - CloseUpMedia - newsdesk@closeupmedia.com Breakthrough genetic research to map all the genes connected to Alzheimer's, which could lead to more aggressive treatment and a potential cure for the disease, was the focus of a presentation...

Predictive genetic testing: ethical, legal, and social implications.
IMAGINE VISITING your physician for a routine physical, and he or she recommends that you have a new genetic test run on a small sample of your blood. The doctor informs you that it will indicate your chances for developing certain diseases at some point in the future, including...

Plasma homocysteine levels & 677C [right arrow] T methylenetetrahydrofolate reductase gene polymorphism in patients with coronary artery disease of different severity.
Background & objectives: Numerous studies have identified hyperhomocysteinemia as an independent risk factor for coronary artery disease (CAD). Furthermore, influences of polymorphysim of methylenetetrahydrofolate reductase (MTHFR) on homocysteine levels are documented. However, the relationship between severity of CAD and polymorphism of MTHFR has not been systematically evaluated. The present...

Genetic polymorphisms associated with venous and arterial thrombosis; an overview. (Advances in the Science of Pathology).
Thrombosis, involving either the venous or arterial systems, is one of the major causes of morbidity and mortality. Thrombosis, either alone or together with atherosclerotic vascular disease, is an underlying cause of myocardial infarctions, strokes, pulmonary embolism, and deep vein thrombosis. Thrombophilia is defined as any disorder associated with...

Utilizing genomic DNA purified from clotted blood samples for single nucleotide polymorphism genotyping. (Advances in the Science of Pathology).
The identification of thousands of single nucleotide polymorphisms (SNPs) in the human genome has prompted a rise in population-based research studies designed to link gene-specific SNPs to complex disease states, pharmacogenetic applications, and individual predisposition and susceptibility to diseases. (1,2) For example, SNPs have been associated with increased risk...